Thermo Fisher Scientific BCL-X Polyclonal Antibody
BCL-X 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 완충액에 보존. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within N-terminal human BCL2L1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 0.2% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932462 |
Target Information
The protein encoded by the BCL-X (BCL2L1) gene belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in diverse cellular activities. These proteins are located at the outer mitochondrial membrane and regulate the opening of the mitochondrial channel (VDAC), which controls membrane potential, reactive oxygen species production, and cytochrome C release—key processes in apoptosis.
Alternative splicing produces multiple transcript variants encoding two isoforms:
- The longer isoform functions as an apoptotic inhibitor.
- The shorter isoform functions as an apoptotic activator.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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