Thermo Fisher Scientific ULK2 Monoclonal Antibody (8G3)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.1 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG3, kappa

Class

Monoclonal

Type

Antibody

Clone

8G3

Immunogen

ULK2 (AAH34988, 743 a.a. approximately 843 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ULK2,uniProtId:Q8IYT8-1,ncbiNodeId:9606,antigenRange:743-843,antigenLength:1036,antigenImageFileName:H00009706-M08_ULK2_Q8IYT8-1_House_mouse.svg,antigenImageFileNamePDP:H00009706-M08_ULK2_Q8IYT8-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: FLRTRTTSVG PSNSGGSLCA MSGRVCVGSP PGPGFGSSPP GAEAAPSLRY VPYGASPPSL EGLITFEAPE LPEETLMERE HTDTLRHLNV MLMFTECVLD L

Target Information

ULK2, also known as ATG1B, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK2 results in a severe defect in the autophagy pathway. ULK2 is highly conserved among eukaryotes and shows high homology with its related protein ULK1. Both ULK1 and ULK2 form a complex with ATG13 and FIP200 that mediates TOR signaling and is essential for autophagy. Like ULK1, ULK2 is also thought to be involved in early neuronal growth and differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.