Thermo Fisher Scientific IL-10 Recombinant Rabbit Monoclonal Antibody (1P10I3)
IL-10 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Western blot에 최적화되어 있습니다. 높은 특이성과 재현성을 제공하며, HEK293 세포에서 발현되었습니다. 면역조절 및 염증 연구에 적합한 연구용 항체입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1P10I3 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 19–178 of rat IL10 (NP_036986.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.22 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3093102 |
Product Specific Information
Immunogen sequence:
SKGHSIRGDN NCTHFPVSQT HMLRELRAAF SQVKTFFQKK DQLDNILLTD SLLQDFKGYL GCQALSEMIK FYLVEVMPQA ENHGPEIKEH LNSLGEKLKT LWIQLRRCHR FLPCENKSKA VEQVKNDFNK LQDKGVYKAM NEFDIFINCI EAYVTLKMKN
Target Information
IL-10 (Interleukin-10) encodes a cytokine primarily produced by monocytes, with additional production by lymphocytes.
This cytokine plays a critical role in immunoregulation and inflammation by:
- Down-regulating Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages
- Enhancing B cell survival, proliferation, and antibody production
- Blocking NF-kappa B activity
- Regulating the JAK-STAT signaling pathway
Knockout studies in mice indicate IL-10 is essential for intestinal immune homeostasis.
Mutations in IL10 are linked to increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Associated diseases include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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