Thermo Fisher Scientific IREB2 Recombinant Rabbit Monoclonal Antibody (4I4R1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:8,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:800

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4I4R1

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 700-963 of human IRP2 (NP_004127.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IREB2,uniProtId:P48200-1,ncbiNodeId:9606,antigenRange:700-963,antigenLength:963,antigenImageFileName:MA5-51268_IREB2_P48200-1_Rabbit.svg,antigenImageFileNamePDP:MA5-51268_IREB2_P48200-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_3094247

Product Specific Information

Immunogen sequence: SLEAPDSVLF PWDLKSTYIR CPSFFDKLTK EPIALQAIEN AHVLLYLGDS VTTDHISPAG SIARNSAAAK YLTNRGLTPR EFNSYGARRG NDAVMTRGTF ANIKLFNKFI GKPAPKTIHF PSGQTLDVFE AAELYQKEGI PLIILAGKKY GSGNSRDWAA KGPYLLGVKA VLAESYEKIH KDHLIGIGIA PLQFLPGENA DSLGLSGRET FSLTFPEELS PGITLNIQTS TGKVFSVIAS FEDDVEITLY KHGGLLNFVA RKFS

Target Information

Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia is important for normal tissue physiology as well as being a component of several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also plays a role during hypoxia (low oxygen).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.