Thermo Fisher Scientific GABRB2 Recombinant Rabbit Monoclonal Antibody (ARC0631)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0631

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 300-400 of human GABA A Receptor beta 2 (GABRB2) (GABRB2) (P47870) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GABRB2,uniProtId:P47870-2,ncbiNodeId:9606,antigenRange:300-400,antigenLength:512,antigenImageFileName:MA5-35130_GABRB2_P47870-2_Rabbit.svg,antigenImageFileNamePDP:MA5-35130_GABRB2_P47870-2_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849035

Product Specific Information

Immunogen sequence: PYVKAIDMYL MGCFVFVFMA LLEYALVNYI FFGRGPQRQK KAAEKAASAN NEKMRLDVNK IFYKDIKQNG TQYRSLWDPT GNLSPTRRTT NYDFSLYTMD P

Target Information

GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.