Thermo Fisher Scientific DRAM Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:2,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:200–1:2,000

Product Specifications

Product Specific Information

• Glycerol (1:1) may be added for additional stability.
• Reconstitute with 150 µL of distilled water.

Target Information

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs simultaneously with activation of proapoptotic genes such as PUMA and Bax, together promoting a full cell death response. DRAM alone cannot induce apoptosis, but its inactivation in certain cancers highlights its importance and suggests autophagy may play a greater role in cancer than previously thought. At least two different isoforms of DRAM are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.