Thermo Fisher Scientific DRAM Polyclonal Antibody
Rabbit polyclonal antibody targeting mouse DRAM, suitable for WB and IHC applications. Lyophilized form for long-term storage at -20°C. Reconstitute with 150 µL distilled water. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:200–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal of mouse DRAM (Damage-regulated autophagy modulator) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10707656 |
Product Specific Information
- Glycerol (1:1) may be added for additional stability.
- Reconstitute with 150 µL of distilled water.
Target Information
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs simultaneously with activation of proapoptotic genes such as PUMA and Bax, together promoting a full cell death response. DRAM alone cannot induce apoptosis, but its inactivation in certain cancers highlights its importance and suggests autophagy may play a greater role in cancer than previously thought. At least two different isoforms of DRAM are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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