Thermo Fisher Scientific CDC6 Recombinant Rabbit Monoclonal Antibody (JE59-52)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JE59-52

Immunogen

Synthetic phospho-peptide corresponding to residues surrounding Ser54 of Human Cdc6 aa 41-90/560. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CDC6,uniProtId:Q99741-1,ncbiNodeId:9606,antigenRange:41-90,antigenLength:560,antigenImageFileName:MA5-50795_CDC6_Q99741-1_Rabbit.svg,antigenImageFileNamePDP:MA5-50795_CDC6_Q99741-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 0.05% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3092989

Product Specific Information

Positive control: Hela cell lysate, HepG2 cell lysate, human striated muscle tissue, human testis muscle tissue.

Predicted band size: 63 kDa

Subcellular Location: Nucleus, Cytoplasm.

Target Information

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.