Thermo Fisher Scientific UCH37 Monoclonal Antibody (854CT5.5.6)
UCH37 단클론 항체로 인간 UCH-L5 단백질을 특이적으로 인식하며 Western blot에 적합. Protein G로 정제된 액상 형태로 제공되며, 4°C 단기·-20°C 장기 보관 가능. 암 연구 및 단백질 유비퀴틴화 관련 기초 연구에 활용.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000–1:4,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 854CT5.5.6 |
| Immunogen | Purified His-tagged UCH37 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.37 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539488 |
Target Information
UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquitinated protein substrates. Since UCH-L5 has the potential to rescue ubiquitinated proteins, including oncogenic proteins, from proteasomal degradation, deregulation of UCH-L5 may affect tumor growth.
Through associations with Smad7, UCH-L5 can dramatically upregulate TGFβ-dependent gene expression by deubiquitinating and stabilizing TGFβ RI. Overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, suggesting that inhibition of these proteins may be of interest for cancer therapy design.
There are four isoforms of UCH-L5 that exist as a result of alternative splicing events.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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