Thermo Fisher Scientific CTLA4 Monoclonal Antibody (OTI3B11)

Applications

• Flow Cytometry (Flow): Tested Dilution 1:400

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor mainly expressed on CD4+ T cells. It binds CD80 and CD86 ligands on B cells and dendritic cells with higher affinity than CD28. Unlike CD28, which enhances T-cell function, CTLA4 inhibits T-cell activity. Intracellular CTLA4 is also found in regulatory T cells and may be essential for their function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.