Thermo Fisher Scientific GITRL Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through activation of NF-kappa-B and mitogen-activated protein kinases.
The glucocorticoid-induced tumor necrosis factor receptor (GITR) is expressed on CD4⁺ CD25⁺ regulatory T cells and plays a crucial role in immune regulation.
Its ligand, GITRL, is expressed in endothelial and antigen-presenting cells, capable of activating NF-kappa-B, inducing both pro- and anti-apoptotic effects, inhibiting the suppressive activity of regulatory T cells, and co-stimulating responder T cells through GITR.
Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappa-B activation, suggesting that the GITRL–GITR pathway involves both NIK and TRAF2.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.