Thermo Fisher Scientific Phospho-Catenin-beta (Ser37) Polyclonal Antibody
Phospho-Catenin-beta (Ser37) 특이적 폴리클로날 항체로, 인간, 마우스, 랫트 시료에서 WB 및 IHC(P) 분석에 적합. 항원 친화 크로마토그래피로 정제되었으며, 세포 내 베타카테닌 신호전달 및 발암 관련 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the epitope SGIHS with a single phosphorylation site at Ser37 of human beta-catenin (UniProt ID: P35222-1, antigen range: 33–37) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human lung adenocarcinoma
- Cellular location: Cytoplasm, Nucleus
Target Information
Beta-catenin is an adherens junction (AJ) protein originally identified as a component of cell-cell adhesion structures. AJs are essential for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin, linking it to alpha-catenin, which anchors the E-cadherin complex to the actin cytoskeleton.
Beta-catenin also associates with cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways involving tyrosine kinases, phosphatases, and Wnt/Wingless. This interplay regulates morphogenesis and cell proliferation.
It is expressed in hair follicle cell types, basal and peripheral matrix cells, and outer/inner root sheath cells. Pathological roles have been identified in pilomatrixoma, medulloblastoma, colorectal, ovarian, and other solid tumors (breast, colon, liver, lung, gastric, prostate, skin). In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, stimulating genes like cyclin D and c-myc that drive proliferation and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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