Thermo Fisher Scientific Catenin-beta Polyclonal Antibody
Rabbit polyclonal antibody against human beta-catenin for WB and IHC applications. Recognizes amino acids 15–41 of beta-catenin. Validated for human, mouse, and rat samples. Supplied as a liquid, 0.5 mg/mL, stored at 4°C or -20°C. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (CQSYLDDSGIHSGAT) of human beta-catenin, corresponding to amino acids 15–41 of the target protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4 °C short term; for long-term storage, store at −20 °C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human lung adenocarcinoma
- Cellular Location: Cytoplasm, Nucleus
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and signaling. It links the cytoplasmic domain of E-cadherin to alpha-catenin, anchoring the E-cadherin complex to the actin cytoskeleton. Beta-catenin also interacts with adenomatous polyposis coli protein, microtubules, and signaling pathways including tyrosine kinases, phosphatases, and Wnt/Wingless.
This protein regulates morphogenesis and is expressed in various hair follicle cell types and epithelial tissues. Abnormal beta-catenin activity is associated with pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and other solid tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting expression of genes such as cyclin D and c-myc that drive cell proliferation and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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