Thermo Fisher Scientific TOP3A Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive Samples: Mouse testis
• Immunogen sequence:
  MILARNYLDV YPYDHWSDKI LPVYEQGSHF QPSTVEMVDG ETSPPKLLTE ADLIALMEKH GIGTDATHAE HIETIKARMY VGLTPDKRFL PGHLGMGLVE

Target Information

DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA by transiently breaking and rejoining DNA strands.
Although DNA topoisomerase I (Topo I) and Topo II relax both positive and negative supercoils, Topo III relaxes only negative supercoils.
Topo IIIα exists as a long and a short isoform, which are produced by alternative splicing. Topo IIIα, which localizes to the nucleolus, is constitutively expressed and remains at high levels throughout the cell cycle in HL-60 cells.
Topo IIIβ exists as three isoforms (β-1, β-2, and β-3), also produced by alternative splicing. Topo IIIβ-1 is expressed in testis, heart, and skeletal muscle, whereas Topo IIIβ-2 is expressed in thymus, kidney, and pancreas.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.