Thermo Fisher Scientific WT1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Positive samples include K-562, 293T, mouse testis, and rat kidney.

Target Information

The Wilms Tumor 1 (WT1) gene encodes one of the WPP domain-interacting proteins required for RanGAP nuclear envelope association in root tip cells. Ran GTPase is essential for nucleocytoplasmic transport, spindle formation, and nuclear envelope reassembly. RanGAP establishes a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with its outer surface in metazoan and plant cells. Arabidopsis thaliana RanGAP association requires nucleoporins with coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WT1 and WIT2 form a second family of CC-TMD proteins, structurally distinct from WIPs, necessary for RanGAP nuclear envelope association in root tip cells.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.