Thermo Fisher Scientific KChIP3 Polyclonal Antibody

Thermo Fisher Scientific KChIP3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total Calsenilin/KCNIP3.

Target Information

Voltage-gated potassium (Kv) channels are key components of potassium currents in the heart and central nervous system.
In the heart, Kv4 channels are involved in the repolarization phase of the action potential.
In the brain, these channels prevent reverse-propagation of action potentials.

Associated with Kv4 channels are calcium-binding proteins termed KChIPs (Kv channel interacting proteins).
KChIPs bind to the cytoplasmic amino termini of Kv4 alpha-subunits and modulate their function.
There are three known KChIPs:

• KChIP1: expressed in the brain
• KChIP2: expressed in brain, heart, and lung (three isoforms: a, b, c)
• KChIP3: also known as calsenilin or DREAM, expressed in brain and testis

KChIP3 acts beyond Kv4 modulation by binding to the regulatory DRE and repressing transcription from the early-response gene c-fos.
It is the first known calcium-binding protein functioning as a DNA-binding transcriptional regulator.
KChIP3 is also associated with presenilins and implicated in beta-amyloid formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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