Thermo Fisher Scientific KChIP3 Polyclonal Antibody
KChIP3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 고순도 Affinity chromatography 정제. 연구용으로만 사용.
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Thermo Fisher Scientific KChIP3 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KCNIP3 (Accession Q9Y2W7), corresponding to amino acid residues R39–T89 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818387 |
Product Specific Information
Antibody detects endogenous levels of total Calsenilin/KCNIP3.
Target Information
Voltage-gated potassium (Kv) channels are key components of potassium currents in the heart and central nervous system.
In the heart, Kv4 channels are involved in the repolarization phase of the action potential.
In the brain, these channels prevent reverse-propagation of action potentials.
Associated with Kv4 channels are calcium-binding proteins termed KChIPs (Kv channel interacting proteins).
KChIPs bind to the cytoplasmic amino termini of Kv4 alpha-subunits and modulate their function.
There are three known KChIPs:
- KChIP1: expressed in the brain
- KChIP2: expressed in brain, heart, and lung (three isoforms: a, b, c)
- KChIP3: also known as calsenilin or DREAM, expressed in brain and testis
KChIP3 acts beyond Kv4 modulation by binding to the regulatory DRE and repressing transcription from the early-response gene c-fos.
It is the first known calcium-binding protein functioning as a DNA-binding transcriptional regulator.
KChIP3 is also associated with presenilins and implicated in beta-amyloid formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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