Thermo Fisher Scientific CXCR3 Polyclonal Antibody
CXCR3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, Flow Cytometry, ELISA 등에 사용 가능. Mouse 및 Rat 반응성, 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
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Thermo Fisher Scientific CXCR3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Flow Cytometry (Flow) | Assay-dependent | View 5 publications |
| ELISA | Assay-dependent | View publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the N-terminus of mouse CXCR3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2534003 |
Target Information
This gene encodes a G protein-coupled receptor with selectivity for three chemokines: IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g), and I-TAC (interferon-inducible T cell chemoattractant).
These chemokines belong to the CXC subfamily, characterized by a single amino acid between the first two conserved cysteines.
Binding of these chemokines induces leukocyte trafficking, integrin activation, cytoskeletal changes, and chemotactic migration.
Inhibition by Bordetella pertussis toxin indicates coupling with Gi-class G proteins.
Signal transduction mechanisms are similar to other chemokine receptors, involving phosphorylation-dependent receptor internalization and recycling.
CXCR3 is highly expressed in effector/memory T cells and in T cells within inflamed tissues.
IP10, Mig, and I-TAC production by local cells suggests a role in recruiting inflammatory cells.
This receptor is a potential therapeutic target for inflammatory diseases.
Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: 71-8800_CXCR3_O88410-1_Rabbit.svg)
(이미지: 71-8800_CXCR3_O88410-1_Rabbit_PDP.jpeg)
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