Thermo Fisher Scientific LNX2 Polyclonal Antibody
LNX2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 ICC/IF에 사용 가능. Human, Mouse, Rat에 반응하며, E3 ubiquitin ligase 연구에 적합. Affinity chromatography로 정제된 0.5 mg/mL 액상 제품으로, 안정적 장기 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–3 µg/mL |
| Immunocytochemistry (ICC/IF) | 3 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Multiple peptides against Human LNX2 (aa 442–458, 129–145, 671–683) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 30% glycerol, 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2532784 |
Product Specific Information
This antibody is predicted to react with Goat, Bovine, Horse, Pig, Cat, and Rabbit.
Target Information
LNX2 (Ligand of Numb Protein X 2) protein is encoded by the LNX2 gene located on chromosome 13 in humans and is also known as PDZRN1 (PDZ domain-containing RING finger 1). Through its PDZ domains, LNX2 forms oligomers and interacts with target proteins. LNX2 functions as an E3 ubiquitin ligase and binds to the Numb protein via NPXY motifs. This interaction facilitates ubiquitination of Numb, preventing proteasomal degradation of Notch intracellular domain (NICD) and modulating the Notch signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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