Thermo Fisher Scientific LNX2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

2-3 µg/mL

-

Immunocytochemistry (ICC/IF)

3 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Multiple peptides against Human LNX2 (aa 442-458, 129-145, 671-683) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LNX2,uniProtId:Q8N448-1,ncbiNodeId:9606,antigenRange:129-145|442-458|671-683,antigenLength:690,antigenImageFileName:720004_LNX2_Q8N448-1_Rabbit.svg,antigenImageFileNamePDP:720004_LNX2_Q8N448-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 30% glycerol, 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2532784

Product Specific Information

This antibody is predicted to react with Goat, Bovine, Horse, Pig, Cat and Rabbit.

Target Information

LNX2 (Ligand of Numb Protein X 2) protein is encoded by the LNX2 gene located on chromosome 13 in humans and is known as PDZRN1 (PDZ domain-containing RING finger 1). It is through its PDZ domains that LNX2 forms oligomers and interacts with some of its target proteins. LNX2 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteasomal degradation of Notch intracellular domain (NICD) and thus modulates the Notch signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.