Thermo Fisher Scientific Phospho-MNK1 (Thr250, Thr255) Polyclonal Antibody
MNK1 단백질의 Thr250/255 인산화 형태를 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 적용 가능. Human과 Mouse 반응성. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MKNK1 (Accession Q9BUB5), corresponding to amino acid residues around phosphorylated Thr250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816699 |
Product Specific Information
This antibody detects endogenous levels of Mnk1 only when phosphorylated at Thr250/255.
Target Information
The MAP kinase-interacting kinases (MKNK1 and MKNK2) are activated by MAP kinases and regulate protein synthesis by phosphorylating eIF4E on Ser209. They may contribute to tumorigenesis. Overexpression of Mnk2 increases phosphorylation of endogenous eIF-4E, indicating its role as an eIF-4E kinase in vivo. Mnk2 may also play a role in responses to environmental stress and cytokines. Expression of active mutants of MNK1 and MNK2 in 293 cells reduces cap-dependent translation relative to cap-independent translation. Human Mnk2 is 94% identical to murine Mnk2 and 71% identical to human Mnk1. In vitro phosphorylation studies show Mnk2 is a better substrate than Mnk1 for Erk2, p38MAPKα, and p38MAPKβ.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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