Thermo Fisher Scientific Phospho-CARD11 (Ser652) Polyclonal Antibody
인산화된 CARD11(Ser652)을 특이적으로 검출하는 폴리클로날 항체로, Western blot에 적합합니다. 사람, 생쥐, 랫트 시료 반응성이 있으며, 고순도 정제 후 PBS/glycerol 용액 형태로 제공됩니다. 연구용으로 NF-κB 관련 신호전달 연구에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CARD11 (Accession Q9BXL7), corresponding to amino acid residues around phosphorylated Ser652 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816701 |
Product Specific Information
This antibody detects endogenous levels of CARD11 only when phosphorylated at Ser652.
Target Information
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, which functions as molecular scaffolds for multiprotein complex assembly at specialized plasma membrane regions. It also belongs to the CARD protein family, characterized by the caspase-associated recruitment domain (CARD). CARD11 has structural similarity to CARD14 and both interact specifically with BCL10, a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, CARD11 activates NF-κB and induces phosphorylation of BCL10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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