Thermo Fisher Scientific PTGS2 Monoclonal Antibody (OTI9H10), TrueMAB
COX2 단백질을 표적으로 하는 인간 반응성 마우스 단클론 항체로, Western blot에 최적화되어 있습니다. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. 염석 후 실험용 접합(conjugation)에 적합합니다.
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Thermo Fisher Scientific PTGS2 Monoclonal Antibody (OTI9H10), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9H10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 18–260 of human PTGS2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
- For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including inflammatory prostaglandins.
This conversion involves two reactions:
- Cyclooxygenase (COX): arachidonate → prostaglandin G2 (PGG2)
- Peroxidase: PGG2 → prostaglandin H2 (PGH2)
COX2 is constitutively expressed in tissues such as endothelium, kidney, and brain, and is up-regulated in pathological conditions (e.g., cancer, inflammation).
Up-regulation is linked to increased cell adhesion, resistance to apoptosis, and tumor angiogenesis.
In cancer cells, COX2 facilitates prostaglandin E2 (PGE2) production, influencing motility, proliferation, and apoptosis resistance.
COX2 is naturally inhibited by calcitriol (active Vitamin D) and repressed by glucocorticoids.
It is also the target of NSAIDs such as aspirin, which reduce pain and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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