Thermo Fisher Scientific CD146 Polyclonal Antibody
CD146 단백질을 인식하는 염소 유래 폴리클로날 항체로, 인간 시료에 반응합니다. Western blot 및 Peptide ELISA에 적합하며, 세포 접착 및 신호전달 연구에 활용됩니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
- 카탈로그번호
- PA5143315
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–0.3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-EPARKEHSGR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933954 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
Target Information
CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed at cell-cell junctions in endothelial cells and various normal and malignant cell types. CD146 functions as a calcium-independent adhesion molecule and may also participate in signal transduction through recruitment of Fyn kinase, influencing actin cytoskeleton assembly. It plays a key role in endothelial cohesion and may contribute to melanoma cell interaction with vascular elements, promoting tumor spread. Additionally, CD146 may function during neural crest development and act as a surface receptor triggering tyrosine phosphorylation of FYN and PTK2, along with transient intracellular calcium increase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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