Thermo Fisher Scientific epithelial Sodium Channel gamma Polyclonal Antibody
Thermo Fisher Scientific의 ENaC gamma 폴리클로날 항체는 인간, 마우스, 랫트 시료에 반응하며 Western blot, IHC, ELISA 등에 사용 가능합니다. KLH 결합 합성 펩타이드로부터 제작되었으며, 고순도의 Protein A 정제 항체입니다. -20°C에서 보관하세요.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human ENaCγ, amino acids 188–290 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share a conserved structure with two short intracellular termini, two membrane-spanning segments, and a large extracellular loop containing a cysteine-rich region.
ENaC has three homologous isoforms: alpha, beta, and gamma. It plays a key role in sodium and fluid balance in kidney, lung, and colon tissues, and mediates aldosterone-dependent sodium reabsorption in the distal nephron, thus regulating blood pressure.
Mutations in ENaC subunits are associated with disorders such as Liddle’s syndrome (gain-of-function) and pseudohypoaldosteronism type 1 (loss-of-function).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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