Thermo Fisher Scientific TRIM71 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TRIM71. Recombinant protein control fragment (Product #RP-96487). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TRIM71,uniProtId:Q2Q1W2-1,ncbiNodeId:9606,antigenRange:472-546,antigenLength:868,antigenImageFileName:PA5-58265_TRIM71_Q2Q1W2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58265_TRIM71_Q2Q1W2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648946

Product Specific Information

Immunogen sequence: IKSFGFVSSG AFAPLTKATG DGLKRALQGK VASFTVIGYD HDGEPRLSGG DLMSAVVLGP DGNLFGAEVS DQQNG

Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.

Target Information

TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development, and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.