Thermo Fisher Scientific HIP1R Polyclonal Antibody
Thermo Fisher Scientific HIP1R Polyclonal Antibody는 인간 HIP1R 단백질을 인식하는 토끼 유래 IgG 항체로, WB, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도 액상 형태로 제공됩니다. 헌팅틴 및 암 관련 연구에 활용 가능합니다.
- 카탈로그번호
- PA558261
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HIP1R. Recombinant protein control fragment (Product #RP-102811). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642442 |
Product Specific Information
Immunogen sequence:
RESQEQGLRQ RLLDEQFAVL RGAAAEAAGI LQDAVSKLDD PLHLRCTSSP DYLVSRAQEA LDAVSTLEEG HAQYLTSLAD ASALVAALTR FSHLAADTII NGGATSHLA
Highest antigen sequence identity to the following orthologs:
- Mouse – 85%
- Rat – 87%
Target Information
Huntingtin disease, a neurodegenerative disorder, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a proapoptotic, cargo-specific adaptor protein potentially involved in the pathogenesis of Huntingtin disease. HIP1R may also participate in clathrin coat recruitment to lipid membranes and contribute to tumorigenesis by promoting survival of precancerous and cancerous cells.
HIP1R expression is significantly associated with prostate and colon cancer metastasis, making it a potential prognostic marker for these cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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