Thermo Fisher Scientific LRP5 Polyclonal Antibody
Thermo Fisher Scientific의 LRP5 Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western Blot과 IHC(Paraffin)에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체로, Wnt 신호 경로 연구에 적합. 장기 보관 시 -20°C에서 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the epitope KATLY of human LRP5 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Positive control: LRP5 transfected HEK293
- Cellular location: Membrane, Endoplasmic reticulum
Target Information
LDL-related proteins, LRP5 and LRP6, belong to the LDL receptor superfamily and are involved in the canonical Wnt signaling pathway.
Mammalian LRP6 binds to Wnt1 and enhances Wnt-induced developmental processes in Xenopus embryos.
Mice lacking LRP6 exhibit developmental defects similar to those caused by deficiencies in various Wnt proteins.
Recent studies show that Wnt proteins induce LRP5 binding to Axin, leading to Axin degradation and β-catenin stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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