Thermo Fisher Scientific LTF Monoclonal Antibody (9C1)
Thermo Fisher Scientific의 LTF Monoclonal Antibody (9C1)는 인간 LTF 단백질을 인식하는 마우스 유래 단클론 항체입니다. Western blot, IHC, ICC/IF 등 다양한 연구 응용에 적합하며, 단백질 G로 정제된 고순도 액상 형태로 제공됩니다. 철 결합 단백질 연구 및 면역 관련 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:1,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9C1 |
| Immunogen | This LTF Monoclonal antibody is generated from mouse immunized with LTF recombinant protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | TBS, pH 7.4, with 1% BSA, 40% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Lactoferrin (LF) is an iron-binding glycoprotein composed of a single ~80 kDa polypeptide chain folded into two homologous lobes, each capable of reversibly binding one ferric ion (Fe³⁺). LF is found in external fluids such as milk and mucosal secretions and is a major component of neutrophil secondary granules.
LF exhibits diverse biological functions, including:
- Regulation of iron homeostasis
- Host defense against microbial infections
- Anti-inflammatory activity
- Regulation of cellular growth and differentiation
- Protection against cancer development and metastasis
LTF serves as a first-line defense against microbial infections through efficient Fe³⁺ binding and removal. It also has bactericidal and proteolytic activities capable of cleaving arginine-rich sequences in microbial proteins. Three isoforms (LTF-α, LTF-β, LTF-γ) have been identified, and LTF receptors are expressed in the gastrointestinal tract, macrophages, lymphocytes, neutrophils, platelets, and some bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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