Thermo Fisher Scientific MMP14 Monoclonal Antibody (3A6)
Human MMP14 단백질을 인식하는 Mouse IgM 단일클론 항체로, WB, ICC/IF, Flow Cytometry에 사용 가능. C-말단(aa 470-499) 펩타이드로 면역화되어 제작됨. Protein G 정제, 0.5 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1:20–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3A6 |
| Immunogen | This MMP14 antibody is generated from mice immunized with a KLH-conjugated synthetic peptide corresponding to amino acids 470–499 of the C-terminal region of human MMP14. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | TBS, pH 7.4, with 1% BSA, 40% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins, which are activated when cleaved by extracellular proteinases. However, MMP14 belongs to the membrane-type MMP (MT-MMP) subfamily, whose members contain a transmembrane domain, indicating that they are expressed at the cell surface rather than secreted. MMP14 activates MMP2 protein, and this activity may be involved in tumor invasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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