Thermo Fisher Scientific SRC3 Monoclonal Antibody (AX15.3)

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:100

-

Immunoprecipitation (IP)

Assay-dependent

-

ChIP assay (ChIP)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

AX15.3

Immunogen

GST fusion protein encoding amino acid residues 605-1294 of human AIB1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SRC3,uniProtId:Q9Y6Q9-1,ncbiNodeId:9606,antigenRange:605-1294,antigenLength:1424,antigenImageFileName:MA1-845_SRC3_Q9Y6Q9-1_House_mouse.svg,antigenImageFileNamePDP:MA1-845_SRC3_Q9Y6Q9-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

purified

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_325446

Product Specific Information

MA1-845 detects amplified in breast cancer-1 (AIB1) in human cells.

MA1-845 has been successfully used in Western blot and immunoprecipitation, ChIP, and immunohistochemistry procedures. By Western blot, this antibody detects an ~155 kDa protein representing AIB1 from MCF-7 cell extract.
The MA1-845 immunizing peptide corresponds to amino acid residues 605-1294 of human AIB1.

Target Information

AIB1-AC3 recognizes AIB1, a member of the SRC-1 family of nuclear receptor coactivators with an apparent molecular weight of 160kDa. The AIB1 gene has been mapped to region 20q12 and has been shown to be amplified in breast tumors and pancreatic cancer cell lines. AIB1 interacts in a ligand-dependent fashion with the estrogen receptor to enhance estrogen-dependent transcriptional gene activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.