Thermo Fisher Scientific CD46 Recombinant Rabbit Monoclonal Antibody (JB25-49)
CD46 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF 등에 적합. 높은 특이성과 재현성을 제공하며, 다양한 인체 조직에서 양성 대조군으로 사용 가능. 단백질 A로 정제된 액상 형태로 안정적 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:800 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JB25-49 |
| Immunogen | Synthetic peptide within Human CD46 (aa 31–80) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_2848627 |
Product Specific Information
Positive Control: Siha, HUVEC, PC-3M, rat kidney tissue, human colon cancer tissue, human breast tissue, human placenta tissue.
Target Information
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments. It regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alters T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 protects placental tissue and is expressed on the inner acrosomal membrane of spermatozoa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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