Thermo Fisher Scientific PGR Monoclonal Antibody (UMAB137), UltraMAB
인간 프로게스테론 수용체(PGR)를 표적하는 UMAB137 클론 단일클론 항체로, WB, IHC, ICC/IF, Flow Cytometry에 적합합니다. 무보존제, 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific PGR Monoclonal Antibody (UMAB137), UltraMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:200 |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB137 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–298 of human PGR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The progesterone receptor (PR) is a nuclear receptor mediating the physiological effects of progesterone, essential for reproductive processes such as pregnancy establishment and maintenance.
PR exists in two forms:
- Form A (94 kDa)
- Form B (120 kDa)
PR-B is the transcriptionally active form responsible for gene activation related to endometrial maintenance and ovulation inhibition.
PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
Upon progesterone binding, PR undergoes conformational change, dimerizes, and binds to progesterone response elements (PRE) to activate transcription.
Null mutations in the PGR gene cause reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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