Thermo Fisher Scientific PGR Monoclonal Antibody (UMAB137), UltraMAB

Thermo Fisher Scientific PGR Monoclonal Antibody (UMAB137), UltraMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The progesterone receptor (PR) is a nuclear receptor mediating the physiological effects of progesterone, essential for reproductive processes such as pregnancy establishment and maintenance.
PR exists in two forms:

• Form A (94 kDa)
• Form B (120 kDa)

PR-B is the transcriptionally active form responsible for gene activation related to endometrial maintenance and ovulation inhibition.
PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
Upon progesterone binding, PR undergoes conformational change, dimerizes, and binds to progesterone response elements (PRE) to activate transcription.
Null mutations in the PGR gene cause reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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