Thermo Fisher Scientific SENP6 Polyclonal Antibody
SENP6 단백질을 표적하는 Thermo Fisher Scientific의 토끼 다클론 항체. Western blot 및 파라핀 포매 조직의 면역조직화학(IHC) 분석에 적합. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 인간 및 랫트 시료에 반응. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1040–1089 of Human SENP6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718914 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Ubiquitin-like molecules (UBLs), such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins in a similar manner. Unlike ubiquitin, covalent attachment of UBLs does not lead to degradation of modified proteins. SUMO1 modification is involved in the targeting of RANGAP1 to the nuclear pore complex and stabilization of I-kappa-B-alpha from degradation by the 26S proteasome.
UBLs are synthesized as precursor proteins and require removal of tail sequences by UBL-specific proteases such as SENP6 before conjugation to target proteins. SENP6 also exhibits isopeptidase activity for deconjugation of SUMO-conjugated substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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