Thermo Fisher Scientific Phospho-CDK9 (Thr186) Polyclonal Antibody
Phospho-CDK9 (Thr186) 항체로 Western blot 및 ELISA에 적합. Human, Mouse, Rat 반응성. Rabbit Polyclonal 형식, Affinity 정제, PBS/glycerol buffer에 보관. 세포 성장 및 전사 조절 연구에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around T186 of human CDK9 (NP_0012521) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.72 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901846 |
Product Specific Information
- Positive Samples: NIH/3T3
- Immunogen Sequence: RYTNR
Target Information
CDK9 is a serine/threonine kinase that forms an active holoenzyme complex with CyclinT1, playing a key role in regulating the eukaryotic cell cycle. It regulates cytokine-inducible transcription networks by facilitating promoter recognition of target transcription factors and promotes RNA synthesis related to cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity toward the CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 can cause cardiac myocyte enlargement, leading to cardiac hypertrophy and an increased risk of heart failure.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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