Thermo Fisher Scientific LRRC25 Monoclonal Antibody (OTI1C5), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Flow Cytometry (Flow)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

LRRC25 plays a role in the inhibition of RLR-mediated type I interferon signaling by targeting DDX58/RIG-I for autophagic degradation.
It interacts with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1, mediating DDX58 degradation via selective autophagy (PubMed:29288164).
LRRC25 also contributes to the inhibition of NF-kappa-B signaling and inflammatory responses by promoting degradation of p65/RELA. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.