Thermo Fisher Scientific TH Monoclonal Antibody (OTI3G3), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting.
(Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882)

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters — dopamine, epinephrine, and norepinephrine.
Catecholamine synthesis is regulated by the interaction of TH with tetrahydrobiopterin (BH4), which binds to the catalytic domain to activate the enzyme.
In humans, four TH mRNA splice variants (hTH1–hTH4) exist, differing in their N-terminal regulatory domains while sharing identical catalytic domains.
TH catalyzes the conversion of L-tyrosine to L-dopa and plays a key role in adrenergic neuron physiology.
Alterations in TH function are associated with neuropathogenic diseases such as Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and cardiovascular disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.