Thermo Fisher Scientific CUEDC2 Polyclonal Antibody
Thermo Fisher Scientific의 CUEDC2 폴리클로날 항체는 인간 단백질 CUEDC2를 특이적으로 인식합니다. IHC(P)에서 검증되었으며, 단백질 A 정제 및 PBS/BSA 버퍼에 보관됩니다. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acid 50–100 of human CUEDC2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540801 |
Target Information
The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, approximately 40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation.
CUE domains are present in eukaryotic proteins involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found.
CUEDC2 (CUE domain-containing protein 2) was identified through yeast two-hybrid screening as a protein interacting with the progesterone receptor (PR), promoting progesterone-induced PR degradation via the ubiquitin-proteasome pathway.
CUEDC2 also decreases PR sumoylation and interacts with IKK-alpha and IKK-beta, reducing NF-kappa-B activation by downregulating IKK activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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