Thermo Fisher Scientific AIRE Polyclonal Antibody
AIRE 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 최적화된 제품으로, 0.5 mg/mL 농도의 액상 형태. 면역조절 관련 연구용으로 사용되며, 장기 보관 시 -20°C에서 안정적.
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Thermo Fisher Scientific AIRE Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 4–6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (34 DHDVVPEDKFQETLHLKEKE 53) of AIRE/APECED protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2540799 |
Target Information
AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression. It is a nuclear protein composed of 545 amino acids with an HSR domain, two PHD-type zinc fingers, and a SAND domain, and may exist in soluble high-molecular-weight complexes.
AIRE may form homodimers, homotetramers, and nuclear bodies, and interacts with transcriptional coactivators CBP and CREBBP. Three isoforms of AIRE are reported, with one predicted to be a candidate for nuclear-mediated decay (NMD).
AIRE plays a role in immune regulation and mediates E3 ubiquitin ligase activity. Defects in AIRE cause the rare autosomal-recessive autoimmune disease autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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