Thermo Fisher Scientific CD104 (Integrin beta 4) Monoclonal Antibody (439-9B), eFluor 660, eBioscience

Thermo Fisher Scientific CD104 (Integrin beta 4) Monoclonal Antibody (439-9B), eFluor 660, eBioscience

Applications and Tested Dilution

Product Specifications

Product Specific Information

The monoclonal antibody 439-9B recognizes human CD104 (integrin beta 4), a 202 kDa subunit that associates with integrin alpha 6 (CD49f) to form the laminin receptor. Expression occurs in epithelial and tumor cells and is involved in cell-matrix and cell-cell interactions. CD104 plays a key role in tumorigenicity.
This antibody crossreacts with bovine and is reported for use in flow cytometric analysis. Tested using A549 cell line at ≤1 µg/test (100 µL final volume). Optimal titration is recommended for best assay performance.
eFluor® 660 replaces Alexa Fluor® 647, emits at 659 nm, and is excited by the red laser (633 nm). Ensure instrument compatibility.
Excitation: 633–647 nm; Emission: 668 nm; Laser: Red Laser.
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

Integrins are heterodimeric transmembrane glycoprotein receptors composed of alpha and beta subunits. They mediate cell-matrix and cell-cell adhesion and regulate gene expression and growth. The integrin beta 4 subunit serves as a laminin receptor and associates with the alpha 6 subunit, playing a critical role in invasive carcinoma biology.
Mutations in the gene encoding integrin beta 4 are linked to epidermolysis bullosa with pyloric atresia. Multiple splice variants exist, encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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