Thermo Fisher Scientific mGluR2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human mGluR2 for IHC(P) applications. Recognizes N-terminal extracellular domain peptide. High species cross-reactivity and purified by antigen affinity chromatography. Supplied as liquid form, 1 mg/mL in PBS with s...
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Applications
Tested Application and Dilution
- Immunohistochemistry (Paraffin) [IHC(P)]: 10–20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate, Rabbit |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from N-terminal extracellular domain of human GRM2 / MGLUR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550321 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- 100%: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Rabbit
- 95%: Mouse, Rat, Bovine, Dog, Bat, Elephant, Panda
- 89%: Hamster, Horse, Platypus
- 84%: Pig
For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels such as NMDA, AMPA, and kainate receptors that mediate fast excitatory synaptic transmission.
Recently, glutamate has also been shown to regulate enzymes producing second messengers via G-protein-coupled receptors, known as metabotropic glutamate receptors (mGluRs).
- Group I receptors (mGluR1a, mGluR5): stimulate phospholipase C and increase phosphoinositide turnover and calcium release.
- Group II and III receptors (mGluR2, mGluR3): inhibit adenylyl cyclase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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