Thermo Fisher Scientific LDHA Recombinant Superclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–3 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 5 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Cat, and Pig.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are composed of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies. Each lot contains a defined mixture of light and heavy chains, ensuring reproducibility and eliminating biological variability.
Note: Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. The product and performance remain unchanged.

Target Information

Lactate dehydrogenase (LDH) is a key enzyme in the glycolytic pathway that catalyzes the conversion of pyruvate to lactate, coupled with NADH/NAD⁺ interconversion. In mammals, LDH is encoded by three genes:

• LDHA (M or muscle form)
• LDHB (H or heart form)
• LDHC (X or testis form)

The three human LDHs share 84–89% sequence similarity and 69–75% amino acid identity. There are five LDH isoenzymes based on the ratio of M and H chains in the tetrameric structure. LDHA expression is hypoxia-inducible and regulated by HIF1α activity. LDHB is often upregulated in cancers.
Mutations in the LDHA gene can lead to Glycogen Storage Disease 11 (GSD11).

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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