Thermo Fisher Scientific SARS-CoV-2 Spike Protein (RBD) Chimeric Recombinant Human Monoclonal Antibody (Sb#42)
SARS-CoV-2 Spike Protein RBD에 특이적으로 결합하는 재조합 인간 단클론 항체. ELISA 및 기능적 억제 분석에 사용 가능. HEK293 발현 시스템에서 생산된 IgG1 형 항체로, Protein A로 정제됨. 연구용으로만 사용.
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Applications
ELISA
- Assay-dependent
Functional Assay
- Assay-dependent
Inhibition Assays
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Human / IgG1, Fc |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Sb#42 |
| Immunogen | This clone was originally isolated in a form of a synthetic nanobody (sybody) via a target swap selection procedure against RBD-vYFP using ribosomal display and against RBD-Fc fusion during phage display rounds. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody recognizes and binds the SARS-CoV-2 C-terminal receptor binding domain (RBD) located in the extracellular portion of the spike protein.
Target Information
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), also known as 2019-nCoV (2019 Novel Coronavirus), causes illnesses ranging from mild cold-like symptoms to severe respiratory distress and death.
The CoV Spike (S) protein plays critical roles in viral attachment, fusion, and entry, serving as a key target for antibody, inhibitor, and vaccine development.
The receptor-binding domain (RBD, S-RBD) of the Spike protein binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors, exhibiting higher affinity than SARS-CoV RBD.
S1 contains an RBD that specifically interacts with ACE2 receptors on target cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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