Thermo Fisher Scientific KCNK18 Polyclonal Antibody
KCNK18 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 적합합니다. Mouse와 Rat 시료에 반응하며, 동결건조 형태로 제공됩니다. 연구용으로 TRESK 채널 관련 신경 및 면역 기능 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of mouse KCNK18 conjugated to an immunogenic carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: KCNK18.
Target Information
TRESK (TWIK-related spinal cord K⁺ channel) is a two-pore domain K⁺ channel that induces outward rectification and functions as a background K⁺ channel. It is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes.
TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It is suggested that TRESK is linked to acute and chronic pain via calcineurin activation. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be a potential target for treating T-cell-originated immune dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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