Thermo Fisher Scientific BMPR2 Monoclonal Antibody (1F12)
BMPR2 단백질을 검출하기 위한 Thermo Fisher Scientific의 단클론 항체. Western blot, IHC, ELISA 등 다양한 응용에 적합. 인간, 마우스, 비인간 영장류, 랫트 시료에 반응. 비결합형 액상 형태로 장기보관 시 -20°C에서 안정적.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | - | 1 publication |
| ELISA | 1:10,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1F12 |
| Immunogen | Purified recombinant fragment of human BMPR2 expressed in E. Coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_11153401 |
Product Specific Information
MA5-15826 targets BMPR2 in indirect ELISA, IHC, and WB applications and shows reactivity with Human, Mouse, Non-human primate, and Rat samples.
The immunogen is a purified recombinant fragment of human BMPR2 expressed in E. coli.
MA5-15826 detects BMPR2 with a predicted molecular weight of approximately 115 kDa.
Target Information
BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases.
BMP ligands are involved in endochondral bone formation and embryogenesis.
Loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to primary pulmonary hypertension (PPH) pathogenesis.
BMPR2 also plays a vital role in human T-cell differentiation.
Type II receptors bind ligands independently but require type I receptors for signaling, while type I receptors need type II receptors for ligand binding.
Mutations in BMPR2 are associated with familial and drug-induced primary pulmonary hypertension and pulmonary venoocclusive disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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