Thermo Fisher Scientific LXR alpha Recombinant Superclonal Antibody (12HCLC)

Applications

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Horse, and Rabbit.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.

While functionally similar to polyclonal antibodies—recognizing multiple epitope sites and providing higher sensitivity for low-abundance targets—Superclonal™ antibodies have a defined mixture of light and heavy chains, enabling reproducible lot-to-lot production and eliminating biological variability.

Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and performance remain unchanged.

Target Information

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor with ligand-dependent transcriptional activation activity. It interacts with retinoic acid receptor (RXR), converting RXR from a silent DNA-binding partner to an active ligand-binding subunit that mediates retinoid responses through LXRES target genes.

LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays a key role in cholesterol homeostasis by regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also functionally interacts with RORA to regulate genes involved in liver metabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.