Thermo Fisher Scientific Mast Cell Chymase Polyclonal Antibody
Human mast cell chymase를 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:1,000~1:2,500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer로 안정화. 심혈관 연구 및 mast cell 관련 단백질 분석에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CMA1. Recombinant protein control fragment (Product #RP-101142) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.30 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791269 |
Product Specific Information
Immunogen sequence:
GRTGVLKPGS DTLQEVKLRL MDPQACSHFR DFDHNLQLCV GNPRKTKSAF KGDS
Target Information
This gene product is a chymotryptic serine proteinase belonging to the peptidase family S1. It is expressed in mast cells and functions in:
- Degradation of extracellular matrix
- Regulation of submucosal gland secretion
- Generation of vasoactive peptides
In cardiovascular tissues, it converts angiotensin I to angiotensin II, contributing to blood pressure control and the pathogenesis of hypertension, cardiac hypertrophy, and heart failure.
This gene maps to 14q11.2 in a cluster of protease-encoding genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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