Thermo Fisher Scientific HGF Monoclonal Antibody (OTI2F3), TrueMAB
HGF 단백질을 인식하는 Mouse monoclonal 항체로 Western blot 및 IHC(P) 적용 가능. Human 시료 반응성. TrueMAB 형식으로 고순도 정제 및 안정적 액상 형태 제공. 세포 성장 및 형태 형성 연구에 적합.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 200–494 of human HGF produced in E. coli. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Hepatocyte growth factor (HGF) regulates cell growth, motility, and morphogenesis by activating a tyrosine kinase signaling cascade via the c-Met receptor. Secreted by mesenchymal cells, HGF acts as a multifunctional cytokine on epithelial cells. It promotes mitogenesis, cell motility, and matrix invasion, playing a key role in angiogenesis, tumorigenesis, and tissue regeneration. HGF is secreted as an inactive single-chain precursor and cleaved into active α (69 kDa) and β (34 kDa) chains linked by a disulfide bond. Although part of the plasminogen subfamily of S1 peptidases, it lacks protease activity. Multiple transcript variants exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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