Thermo Fisher Scientific SETD6 Recombinant Rabbit Monoclonal Antibody (1Q1Z3)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:5,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

1Q1Z3

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 310-473 of human SETD6 (NP_001153777.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SETD6,uniProtId:Q8TBK2-1,ncbiNodeId:9606,antigenRange:310-473,antigenLength:473,antigenImageFileName:MA5-51377_SETD6_Q8TBK2-1_Rabbit.svg,antigenImageFileNamePDP:MA5-51377_SETD6_Q8TBK2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.63 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_3094297

Product Specific Information

Immunogen sequence: TADIQMVTVR EAALQGTKTE AERHLVYERW DFLCKLEMVG EEGAFVIGRE EVLTEEELTT TLKVLCMPAE EFRELKDQDG GGDDKREEGS LTITNIPKLK ASWRQLLQNS VLLTLQTYAT DLKTDQGLLS NKEVYAKLSW REQQALQVRY GQKMILHQLL ELTS

Target Information

SETD6 (SET domain-containing protein 6) is a 473 amino acid protein that belongs to the SETD6 family. Containing one SET domain, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. SETD6 is a proteinlysine N-methyltransferase that specifically monomethylates Lys-310 of the NFκB p65 subunit of NFκB complex, leading to down-regulate NFκB transcription factor activity. SETD6-mediated methylation renders NFκB p65 inert and attenuates NFκB p65-driven transcriptional programs, including inflammatory responses in primary immune cells. The SETD6-initiated lysine-methylation signaling cascade acts to restrain activation of NFκB-mediated inflammatory responses in diverse cell types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.