Thermo Fisher Scientific CXCR3 Polyclonal Antibody
CXCR3 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체로, Western blot, IHC, ICC/IF, Flow cytometry에 사용 가능. 인간 시료 반응성, 0.5 mg/mL 농도, TBS 버퍼에 0.5% BSA 포함. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 6–8 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-RRDSSWSETSEA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2932873 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
This gene encodes a G protein-coupled receptor with selectivity for three chemokines: IP10 (interferon-gamma-inducible 10 kDa protein), Mig (monokine induced by interferon-gamma), and I-TAC (interferon-inducible T cell alpha-chemoattractant).
These chemokines belong to the CXC subfamily, characterized by a single amino acid separating the first two of four conserved cysteine residues.
Binding of chemokines to CXCR3 induces leukocyte trafficking responses, including integrin activation, cytoskeletal rearrangement, and chemotaxis.
This receptor couples with Gi-type G proteins, and its signaling involves phosphorylation-dependent receptor internalization and recycling.
CXCR3 is highly expressed in effector/memory T cells and inflamed tissues, playing a key role in inflammatory cell recruitment.
It is also a potential target for small-molecule antagonists in inflammatory disease therapy.
Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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