Thermo Fisher Scientific mGluR5 Monoclonal Antibody (1A11D10)
mGluR5 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, ICC, Flow cytometry, ELISA에 사용 가능. Human 시료에 반응하며, Protein G로 정제된 1 mg/mL 액상형 제품. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A11D10 |
| Immunogen | Purified recombinant fragment of human GRM5 (AA: extra 458–580) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091217 |
Target Information
GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of the Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein-mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 can be inhibited by recoverin, a calcium-binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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