Thermo Fisher Scientific Collagen Type III Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store vial at 4°C prior to opening. This product is stable at 4°C as an undiluted liquid. Dilute only prior to immediate use.
For extended storage, mix with an equal volume of glycerol, aliquot contents, and freeze at -20°C or below. Avoid freeze/thaw cycles.

Typically negligible cross-reactivity against other types of collagens was detected by ELISA against purified standards.
Some class-specific anti-collagens may be specific for three-dimensional epitopes, which may result in diminished reactivity with denatured collagen or formalin-fixed, paraffin-embedded tissues.
This antibody reacts with most mammalian Type III collagens and has negligible cross-reactivity with Type I, II, IV, V, or VI collagens.
Non-specific cross-reaction with other human serum proteins or non-collagen extracellular matrix proteins is negligible.

Target Information

Collagen III is a fibrillar collagen found in extensible connective tissues such as skin, lung, and the vascular system, often in association with Type I Collagen.
Mutations in the gene are associated with Ehlers-Danlos syndrome type IV and with aortic and arterial aneurysms.
Alternate transcripts detected for this gene are typically mutation-derived, altering splicing and leading to exclusion of multiple exons.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.