Thermo Fisher Scientific Collagen Type II Polyclonal Antibody

Thermo Fisher Scientific Collagen Type II Polyclonal Antibody

Applications 및 Tested Dilution

Product Specifications

Product Specific Information

Store vial at 4°C prior to opening. This product is stable at 4°C as an undiluted liquid. Dilute only prior to immediate use.
For extended storage, mix with an equal volume of glycerol, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing.

Typically negligible cross-reactivity against other types of collagens was detected by ELISA against purified standards.
Some class-specific anti-collagens may be specific for three-dimensional epitopes, which may result in diminished reactivity with denatured collagen or formalin-fixed, paraffin-embedded tissues.
This antibody reacts with most mammalian Type II collagens and has negligible cross-reactivity with Type I, III, IV, V, or VI collagens.
Non-specific cross-reaction of anti-collagen antibodies with other human serum proteins or non-collagen extracellular matrix proteins is negligible.

Target Information

COL2A1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye.
Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type.
Defects in processing chondrocalcin, a calcium-binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.